The deadly accident, involving six vehicles, occurred in the early hours of Sunday morning at the entrance to the underpass on Belgrave Middleway, a busy city center route.
A fleet of ambulances, three paramedic officers and an air ambulance all scrambled to the scene of the crash, the BBC reported.
The West Midlands Police described the scene as "very difficult and upsetting."
In the second vehicle, a taxicab, the driver and a woman passenger died on the scene. Another passenger, a man, was rushed to hospital where he later died of his injuries, The Telegraph wrote.
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Three of the four men traveling in the third car were confirmed dead at the scene, while the fourth was rushed to a hospital where he remains in critical condition.
Of those in the three other cars, two people suffered minor injuries and another two escaped unharmed.
In the three other cars involved in the crash, a man and a woman were treated for minor injuries, one man was discharged after assessment and another said he did not require any assistance.