"I can say unequivocally there is no US government involvement in this at all," Bolton said in a Sunday interview, cited by Reuters.
The senior Trump appointee raised the possibility that Maduro's own government was responsible for the explosions as a move to consolidate power and crack down on the political opposition, noting the five-year collapse of Venezuela's economy and subsequent unrest.
"It could be a lot of things, from a pretext set up by the Maduro regime itself to something else," Bolton claimed, calling on Maduro to show proof of his accusations.
"If the government of Venezuela has hard information that they want to present to us that would show a potential violation of US criminal law, we will take a serious look at it," Bolton stated, cited by Reuters.
Responsibility for the Saturday blasts was claimed by an obscure Caracas paramilitary group describing themselves as ‘National Movement of Soldiers in T-shirts.'
Maduro, his wife and other members of his cabinet were unharmed in the purported attacks.
The oil-rich South American country is undergoing a deep economic crisis, as the fossil-fuel economy suffers from declining revenue and sustainable power technologies such as solar and wind see huge gains in the global energy marketplace.
Out-of-control hyperinflation — coupled with widespread malnutrition — in Venezuela has seen many flee to neighboring Brazil and Colombia.