The Pajhwok news agency reported citing government officials, that Mattis would meet country's President Ashraf Ghani, high-ranking government officials, and US troops.
"There is interest that we've picked up from the Taliban side," Mattis told reporters.
Mattis' previous visit to the country took place in September.
The United States has been present in Afghanistan for almost 17 years following the September 11, 2001 attacks in Washington and New York. Washington and its allies launched a military operation in Afghanistan in 2001, which ended in 2014. However, on January 1, 2015, NATO announced Operation Resolute Support to train and assist the Afghan security forces.
*Taliban is an organization banned in Russia