The United Nations General Assembly on Thursday voted in favor of the resolution to end the US economic and financial embargo imposed on Cuba, President Maria Fernanda Espinosa announced.
"The result of the vote is as follows: in favor 189, against two, abstentions zero, "Espinosa said. "The draft resolution is therefore adopted."
The vote was the 27th attempt at the General Assembly to end the US embargo against Cuba that has been in place for more than 55 years.
The United States and Israel voted against the resolution, as has been the case in all but one year since Cuba began introducing a similar resolution in 1992.
However, the US will ban transactions with more than 20 Cuban entities associated with Cuba's military and intelligence services, White House National Security Adviser John Bolton said on Thursday during remarks on the Trump administration's policies in Latin America.
"I believe within days the administration will add over two dozen additional entities owned or controlled by the Cuban military and intelligence services to the restrictive list of entities with which financial transactions by US persons are prohibited," Bolton said.
The only time the United States did not cast a no vote was when it abstained in 2016 during the period of rapprochement between Washington and Havana during the Obama administration.
The vote follows Cuban Ambassador's to Russia, Gerardo Penalver Portal, earlier statement that Cuba has lost more than $4 billion over the past 12 month due to the US sanctions policy targeting Havana.
Prior to Thursday's vote, the General Assembly rejected eight human-rights related amendments that were introduced by the United States, with no votes ranging from 113 to 114 and abstentions from 65 to 67 nations. Ukraine joined the United States and Israel in voting to approve all eight amendments.
Relations between Washington and Havana have chilled during the Trump administration, with the United States now accusing Cuba of taking advantage of the Obama-era thaw to crack-down on dissent.