The crash happened at 5:45 p.m. in the Villers-Agron-Aiguizy commune on the highway between Paris and Reims, according to a statement on the prefect’s Twitter page.
Two children were critically injured and taken to hospital in the city of Reims, while five other minors and two adults received moderate injuries.
French authorities said the bus was carrying 41 passengers when it was hit. The number of children was not reported. It was not immediately known what caused the collision.