"On Tuesday, May 4, 2021, emergency personnel responded to a report of a downed aircraft on Annie Christie Drive around 11:20 p.m. [04:20 GMT]. When emergency crews arrived on scene, it was confirmed that a civilian aircraft had crashed into a home", Hattiesburg Police Department tweeted.
The Federal Aviation Administration was contacted to handle the investigation, according to the statement.
"At this time we can confirm for you that in total there are four fatalities", police spokesman Ryan Moore told local broadcaster WDAM.
The traffic in the area surrounding was shut down for emergency services access, but later partially restored.