Media reported that the law enforcement responded to a shooting call at Midland Avenue at around 09:02 p.m. on Thursday (01:02 GMT on Friday).
"We have five victims total. The ages range from eight years old to 35 years old, both male and female victims," Syracuse Police Chief Frank Fowler told reporters, CNYCentral, a local NBC and CBS TV news affiliate, reported.
"This is a very tragic event," Fowler said. "This is something that cannot occur in our community. I can tell you right now there are folks out there who have information about what happened here tonight and there are a lot of people that are standing around me that are completely outraged and heartbroken tonight and this type of investigation deserves closure."
According to the TV news affiliate, police are investigating another shooting on Furman Street, where a 14-year-old girl sustained a gunshot wound. It is, however, unclear if the incident is related to the Midland Avenue shooting.
The United States has been facing repeated shootings, prompting protests against loopholes in the country’s gun control legislation.