"Only the ones who did not experience the Cold War can like it. The anti-Russia approach in Europe will lead nowhere," Renzi told the Italian Sky TG24 TV channel in an interview.
Italy has been long asking Russia to return to cooperation with the Western countries, the prime minister added.
Renzi has been repeatedly voicing support for Russia and maintaining dialogue with Moscow, even amid deteriorating Russia's relations with the EU members states and the United States.
On Tuesday, Renzi said the Italian people could trust Russian President Vladimir Putin regarding the issues of international stability.