The shooting occurred at 11:45 p.m., local time, on Friday (06:45 GMT on Saturday) in the area of Front Street and L Street in Old Sacramento, police said on Facebook.
"In total, six shooting victims were located surrounding this incident. Of the six, two victims who are believed to be adult males were pronounced deceased. The other four victims received treatment at local hospitals for non-life-threatening injuries," police said.
According to the Sacramento police department, the shooting was likely an isolated incident and a homicide investigation is underway.
"The investigation is still in its early stages and the motive is unknown, however it is believed that there was some type of altercation between two groups prior to the shooting and multiple firearms have been recovered at the scene," police specified.
No information on a suspect has been released.