When asked if he thought Cuomo should resign if the investigation confirms sexual misconduct, Presient Biden briefly said "yes".
"I think he'll probably end up being prosecuted, too", the president added.
At the same time, Biden noted that there should be an investigation to determine whether the allegations levelled by several women were true.
Cuomo vowed last week not to bow to political pressure and step down over allegations that he sexually harassed and assaulted women who worked under him, saying he was confident a state investigation would clear him of any wrongdoing.
New York Attorney General Letitia James has opened an independent investigation into the allegations. Dozens of US politicians have called on Cuomo to step down over the sex scandal.