The draw for the third qualifying round of Europe's most prestigious club competition took place Friday at UEFA HQ in Nyon, Switzerland.
Spartak will play the winners of the second qualifying round tie between Dynamo Kiev and the Irish champions, Drogheda United. The Ukrainians won the first leg in Ireland 2-1 and are overwhelming favorites to make the next round.
Spartak and Dynamo have a long rivalry stretching back to the Soviet era, when the two sides regularly battled for honors. Their meetings since the breakup of the Soviet Union have been a lot less frequent, but the rivalry between the fans has lost none of its edge.
The two sides last met in Israel in the pre-season Channel One Cup. Dynamo Kiev, currently managed by former Lokomotiv Moscow trainer, Yuri Syomin, ran out convincing 3-0 winners.
Both sides finished second in their respective championships last year.
The first leg of the tie will take place in Moscow.
Other third round qualifying ties include FC Twente, managed by former England manager, Steve McClaren, against Arsenal. Barcelona, who beat Arsenal in the 2006 Champions League final, take on the winners of Moldova's FC Sherif and Sparta Prague. Liverpool will face the Belgians Standard Liege.
The matches will take place on August 12/13 and August 26/27.
Russian champions Zenit St. Petersburg, who on Friday tuned down an offer from Tottenham Hotspur for their striker Andrey Arshavin, will enter the tournament in the group stage, which begins on September 16.