"The cry of these children and their parents rise up to God," Pope Francis stated to the thousands listening in St. Peter's Square and the millions listening online around the world, according to Reuters.
Pope Francis has brought renewed attention to the ongoing war in Yemen, even as a deadly cholera outbreak and continued military operations decimate the population of the poorest nation in the Middle East.
"Let us pray strongly because they are children who are hungry, who are thirsty, they don't have medicine and they are in danger of death," he said, prior to boarding a plane bound for the UAE capital of Abu Dhabi.
With the first visit by a Pope to the Middle East, observers have expressed doubt that he will address the disturbing humanitarian crisis in such strongly-worded terms while within the nation's borders, according to Reuters.
The Pope will meet several Muslim leaders as well as officiate a mass for an estimated 120,000 Catholics in the nation.
The unprecedented visit by a Catholic Pontiff to the Middle East will provide two great faiths the possibility of writing "a new page in the history of relations between religions," he said, cited by Reuters.
The Muslim-majority UAE has been described as a Christian-tolerant nation, although Abu Dhabi takes a dim view of any form of criticism or dissent against its ruling clan, particularly within the social media environment.
The Catholic Pope will meet Abu Dhabi Crown Prince Sheikh Mohammed bin Zayed al-Nahyan — an ally of Saudi Arabia's Crown Prince Mohammed bin Salman — as well as Sheikh Ahmed al-Tayeb, the Grand Imam of Egypt's Al-Azhar mosque and university, within the confines of Abu Dhabi's Sheikh Zayed Grand Mosque, according to Reuters.