Soyuz has brought back a US astronaut Kathleen Rubins, Russia's Anatoly Ivanishin, and Japan's Takuya Onishi, who have carried out 40 experiments while at the station, most of them exploring the influence of the space on live organisms.
Shane Kimbrough, Andrei Borisenko and Sergey Ryzhikov have stayed on the ISS to transfer to the next mission.
The launch of the Soyuz MS 03 spacecraft carrying a new ISS mission is planned for November 17.
