Effective anti-cancer substances can be produced from molecules found in the ordinary parsley and dill seeds , a new study reveals.
Scientists from Moscow Institute of Physics and Technology (PhysTech) and Russian Academy of Sciences have come up with a way to obtain glaziovianin A, a natural component known for its anti-cancerous properties, from parsley and dill.
"Nowadays it is important not only to find new mechanisms to fight cancer, but also improve existing ones," said Alexander Kiselyov, a researcher in the field of medicinal chemistry and drug development from PhysTech. "We have developed a simple method for producing glaziovianin A and its structural analogs, which inhibit the growth of tumor cells, from a cheap raw material."
Chemotherapy, which destroys tumors, works in two ways: either damaging the cancer cells DNA causing them to self-destruct, or inhibiting their growth and division. The second method is becoming more popular since it does not result in the appearance of even more aggressive forms of cancer cells. Drugs of this type called antimitotics destroy tubulin, one of the basic proteins critical for cell division. The antimitotics can be both obtained synthetically and derived from tropical plants.
The method offered by Russian scientists is cheaper existing ones because it involves cheap widespread materials and also reduces the number of steps in its synthesis and the list of catalysts involved.
In addition, Kiselyov and his colleagues have synthesized a number of structural analogs of glaziovianin A in order to find new antimitotics. According to the study published in the Journal of Natural Products, the anti-tumor activity of the analogs has been tested on sea urchin embryos and human cancer cells. The use of sea urchin embryos was another innovation offered by the team of scientists. The cells of these sea creature embryos divide rapidly in the early stages of development, simulating the way a tumor grows. When the antimitotics were added to the sea urchins' substratum, they started to rotate, making it easy for the researchers to evaluate the effect of new drugs and their side effects.
Two "clones" of glaziovianin A could be used in medicine as anti-cancer drugs in future, the scientists considered. However, the best results were demonstrated by glaziovianin A itself. Since the substances have shown efficacy, the authors of the study plan to continue their tests on human cancer cells transplanted into laboratory mice.
The fact of registration and authorization of users on Sputnik websites via users’ account or accounts on social networks indicates acceptance of these rules.
Users are obliged abide by national and international laws. Users are obliged to speak respectfully to the other participants in the discussion, readers and individuals referenced in the posts.
The websites’ administration has the right to delete comments made in languages other than the language of the majority of the websites’ content.
In all language versions of the sputniknews.com websites any comments posted can be edited.
A user comment will be deleted if it:
does not correspond with the subject of the post;
promotes hatred and discrimination on racial, ethnic, sexual, religious or social basis or violates the rights of minorities;
violates the rights of minors, causing them harm in any form, including moral damage;
contains ideas of extremist nature or calls for other illegal activities;
contains insults, threats to other users, individuals or specific organizations, denigrates dignity or undermines business reputations;
contains insults or messages expressing disrespect to Sputnik;
violates privacy, distributes personal data of third parties without their consent or violates privacy of correspondence;
describes or references scenes of violence, cruelty to animals;
contains information about methods of suicide, incites to commit suicide;
pursues commercial objectives, contains improper advertising, unlawful political advertisement or links to other online resources containing such information;
promotes products or services of third parties without proper authorization;
contains offensive language or profanity and its derivatives, as well as hints of the use of lexical items falling within this definition;
contains spam, advertises spamming, mass mailing services and promotes get-rich-quick schemes;
promotes the use of narcotic / psychotropic substances, provides information on their production and use;
contains links to viruses and malicious software;
is part of an organized action involving large volumes of comments with identical or similar content ("flash mob");
“floods” the discussion thread with a large number of incoherent or irrelevant messages;
violates etiquette, exhibiting any form of aggressive, humiliating or abusive behavior ("trolling");
doesn’t follow standard rules of the English language, for example, is typed fully or mostly in capital letters or isn’t broken down into sentences.
The administration has the right to block a user’s access to the page or delete a user’s account without notice if the user is in violation of these rules or if behavior indicating said violation is detected.