The blast caused by an unidentified explosive device went off at 5.00 a.m. Moscow time (2.00 a.m. GMT) in the city's Sovetsky district. The shockwave blew out the windows in nearby shops. No other victims have been reported.
An investigation is underway. Police, special services officers and rescuers are working at the scene.
The victim of the blast has not yet been identified. Investigators have not excluded the possibility that the man had been carrying the explosive device on a bus.
In 2004 the city of Voronezh, located in the same part of the country, was hit by a series of three consecutive blasts at bus stations. One 26-year-old woman was killed and ten other people were injured.