Macron also stressed that France will continue being militarily engaged in the Middle East in the international coalition throughout 2019.
"The announced withdrawal of our American ally should not deflect us from our strategic objective to eradicate Daesh", Macron said on Thursday addressing the armed forces in the French city of Toulouse.
Last month, US President Donald Trump announced that he was ordering a full troop pullout from Syria, saying the war against Daesh was won.
This announced withdrawal was condemned by a number of US officials and resulted in two resignations: US Secretary of Defence Jim Mattis and Brett McGurk, special presidential envoy for the US coalition in Syria.
*Daesh (ISIL/ISIS/Islamic State) is a terrorist group banned in Russia and many other countries.