"Clashes on the eastern border left four Palestinians dead and 618 wounded, seven of them seriously," Gaza Health Ministry spokesman Ashraf Kidra said.
This brought the total death toll among Palestinians protesting the occupation of their native land by Israel past 120, while thousands were hurt by Israeli live fire and tear gas.
The IDF said earlier that its troops had increased security measures along the border with the Gaza Strip in order to protect the Israeli people and the country's infrastructure against the alleged attempts by the Hamas movement, which governs the Gaza Strip, to carry out terrorist attacks.
Tensions between the Israeli and Palestinians flared up amid the Great March of Return rally. The Israeli side has been using lethal arms to suppress the rallies citing security concerns and putting the blame for the escalation on the Hamas radical movement. Since the start of the protests dozens of Palestinians have been killed and thousands injured.