"The United States is deeply concerned about today's escalation of violence over Israel's border and strongly supports Israel's sovereign right to defend itself. Iran's calculated escalation of threat and its ambition to project its power and dominance, places all the people of the region — from Yemen to Lebanon — at risk. The U.S. continues to push back on the totality of Iran's malign activities in the region and calls for an end to Iranian behavior that threatens peace and stability," Nauert said in a statement.
Earlier in the day, the Israeli army said its helicopter intercepted an Iranian drone launched from Syria and that the Israeli Air Force (IAF) struck Iranian targets in Syria, prompting fire from the Syrian air defense systems.
In the second wave of the attack, the Israeli forces struck 12 targets in Syria, including Syrian air defense batteries and Iranian military facilities, the IDF said.
Later, Israeli prime minister Benjamin Netanyahu said during a telephone conversation with Russian President Vladimir Putin that Israel has the right for self-defense and will defend itself against any attack or attempt to violate its airspace.
Meanwhile, Pentagon spokesman Maj. Adrian Rankine-Galloway told Sputnik that the United States is concerned about "destabilizing activities" of Iran and supports Israel's right to defend itself.
The White House also said in a statement that Washington supports Israel's right to defend itself from Iranian-backed militias in Syria and urges Iran and its allies to abstain from provocative actions.