Russia's strategic missile carriers used cruise missiles to strike Daesh and al-Nusra targets in Syria, the statement said.
"All of the targets' coordinates were verified and confirmed by reliable intelligence data," the statement said. "The results of the air and missile strikes were overseen by unmanned aerial vehicles."
Russian air group at Hmeimim airbase and Su-33 aircraft from Admiral Kuznetsov aircraft carrier also took part in the strikes.
According to the ministry's statement, a group of Russian strategic bombers launched cruise missiles from an area over the Mediterranean sea after flying some 11,000 kilometers (some 6,835 miles) from Russian airbases.
Su-33 fighter jets based on Admiral Kuznetsov air carrier and aircraft from the Russian air group at the Hmeimim airbase also took part in the strikes.
"The targets included terrorist command posts, weapons and ammo depots, various military equipment and weapons production facilities," the statement said.
Syria’s Aleppo has been the scene of fierce battles between Syria’s army and militants holding the city's eastern districts. Fighting has escalated in recent days since militants announced an offensive and fired missiles on government-held districts of western Aleppo.
Russia introduced an earlier humanitarian pause in October, to ensure the safe evacuation of civilians and unarmed militants from eastern Aleppo through designated corridors. That pause collapsed when Jabhat Fatah al-Sham (also known as Nusra Front, or Jabhat al-Nusra) militants prevented civilians from fleeing Aleppo and attacked them, prompting an offensive by government forces.