The human rights organization says that at least 300 civilians have been killed in attacks by the coalition since September 2014.
Neil Sammonds, Amnesty International's researcher, told Sputnik that it is clear that the US-coalition is not taking enough precautions in its military operations.
"The US-led coalition does not appear to be making enough of an effort to assess the site that it is going to hit, whether there are civilians in the area. Several times it appears that it targets without a clear military objective, perhaps as a result of inadequate intelligence," Mr. Sammonds told Sputnik.
"Not only is it performing these attacks and killing many civilians, but it is not acknowledging them. In the report issued today [October 26], where there are some 300 civilians likely killed, the United States has only accepted one of these.
"We understand that there are some movements behind the scenes to investigate more thoroughly, but until now it looks like their investigations and acknowledgement processes are not fit for purpose. The amount of force used in carrying out a military operation should be proportionate," Mr. Sammonds added.
Over half of the victims identified in the report were killed during the operation to re-take the city of Manbij from Daesh.
The report has been released as the battle for the city of Mosul intensifies in Iraq, where one million civilians are living.
Mr. Sammonds spoke of his concern that the civilian toll in the battle for Mosul could be even higher.
"Manbij had 70,000 civilians which went down to around 20,000 when the campaign kicked off last summer," Mr. Sammonds said. "About 250 civilians were killed over a few months in several incidents that we include in the report."
"Mosul has about 1.2 million civilians living there. What larger amount of civilians could be killed there? The US needs to learn from its mistakes and learn very quickly."
Amnesty compiled the report through a series of interviews, videos, photographs and reviewing satellite images and reports from local activists. The organization has called for independent investigations into possible violations of international law.
Other groups such as the Syrian Network for Human Rights have estimated the civilian death toll caused by US-coalition bombing to be even greater, with estimates ranging from 600 to 1,000.
Human rights groups have also accused the Russian military operation supporting the regime in Syria of being responsible for the death of civilians. Russia denies the allegations however. Targeting mistakes by members of the US-led coalition occur on a regular basis, while Russia has effective air defense means, which ensure round-the-clock monitoring over Syria, Russian Defense Ministry spokesperson Maj. Gen. Igor Konashenkov said on October 19.