Some 150 Daesh terrorists, including foreign fighters, have been killed as a result of Russia's strikes on Wednesday, the ministry said.
"On August 17, 2016, Russian Su-34 bombers carried out strikes from the Hamadan airfield on the territory of the Islamic Republic of Iran against targets of the Daesh terrorist group in the province of Deir ez-Zor. Aircraft carried high-explosive bombs OFAB-500."
All aircraft of the Russian Aerospace Forces returned to their home bases after carrying out airstrikes on Daesh targets in Deir ez-Zor, the ministry said.
"The Su-35S aircraft based at the Hmeymim airbase [in Syria] provided fighter-bomber air cover for the bombers. After successfully conducting combat missions, all Russian aircraft returned to their home bases."
The Su-34 fighter-bomber has been tested in the war against Islamist radicals in Syria where the aircraft arrived among the first Russian forces in 2015.