The politician argued that the cause of terrorism is the chaos in Syria, caused by the refusal of the current Syrian regime to provide democratic reforms.
During the interview, Simsek argued that the resignation of Syrian President Bashar Assad is an essential precondition for the peace in Syria.
"If Germany and others want to stop the influx of refugees, they must stop the bombings by Syrian and Russian forces against the Syrian opposition," Simsek told the newspaper.
Turkish authorities have repeatedly been criticized by the West for insufficient participation in the fight against terrorism and concentrating their efforts on the war with Kurdish rebels.
"Daesh represents for us the greatest danger," the deputy prime minister said. "We live in the immediate neighborhood. And we constantly face a threat of terrorist attacks," he added.
Previously German newspaper Deutsche Wirtschafts Nachrichten (DWN) reported that in the wake of the mysterious recent attack in Istanbul, Turkey claimed to have launched a major offensive in Iraq and Syria.
An explosion in Istanbul's historical center on Tuesday claimed the lives of at least 10 people, injuring 17 more. Among the victims were at least 10 German nationals.