"Five young people who were injured by Israeli bullets near Beit Hanina [Palestinian neighborhood in East Jerusalem] have been delivered to Shifa Hospital," Palestinian Interior Ministry said in a statement.
An Israeli army spokeswoman estimated that hundreds of people participated in the protest.
Since the beginning of October, over 20 Palestinians and four Israeli nationals have been killed in the clashes.
The Gaza Strip is one of the territories disputed by Israel and the Palestinians, who seek to include the territory in their independent state.
Israel does not recognize Palestine as a political entity.