Pope Francis thanked the firefighters who battled to extinguish the fire at the Notre-Dame Cathedral in Paris on behalf of the entire Catholic Church.
"The gratitude of the whole Church goes to all those who did everything they could, even risking their lives, to save the Basilica," he said during the weekly general audience in Saint Peter's Square.
Francis said he had been "very saddened" by the fire on Monday, which gutted the cathedral.
According to reports, a firefighter suffered injuries during the blaze.
French President Emmanuel Macron has described the incident as a "terrible tragedy" and promised to rebuild the 856-year-old cathedral.
After the tragic fire, the French heritage foundation and the US-based French Heritage Society began fund-raising campaigns to help rebuild the landmark cathedral.