"It is important, once the prime minister has finished her negotiations… that parliament votes on that. If that were not to be successful, we need to have the agreement, we can't just have continuing uncertainty. And I think parliament should be invited to say what it would agree with," Clark told BBC Radio Four broadcaster, when asked if the House of Commons should be allowed to vote on different Brexit options, rather than simply for or against May's deal.
Clark added that businesses across the country would expect the lawmakers to "take responsibility rather than just be critics."
"I spend most of my week talking to businesses, large and small. There is a real demand for the end to the uncertainty, and that is available by endorsing the deal," the business secretary said.
May is expected to make a statement in the parliament later on Monday to warn against a second referendum, as talk about such a vote has grown louder in the last few days. On Sunday, education minister Damian Hinds stressed the government was not making any preparations for a second referendum.