Speaking at a question and answer session in Brussels, European Commission President Jean-Claude Juncker urged Italians "to take care of the poor regions" of the country, which he said "means more work and less corruption."
"We will help them as we always have. But don't play this game of loading the EU with responsibility. A country is a country, a nation is a nation. Countries first, Europe second," Juncker pointed out.
He called for a "silent, prudent and cautious" approach on the matter, saying that he has "full confidence in the genius of the Italian people."
Juncker's remarks come as Italy remains in the grip of political tumult after the country's President, Sergio Mattarella, rejected the formation of a coalition government proposed by the euro-sceptic Lega Party and the Five Star Movement (M5S).
The two parties have accused President Sergio Mattarella of betraying the constitution and demanded early elections.
All this prompted shock waves throughout European, US and Asian stock markets, as the euro plunged against the dollar and the main indexes nose-dived amid concerns for the future of the eurozone.