His rival Stavros Malas from the left-wing Progressive Party of Working People (AKEL) was backed by 44.01 percent of the voters, the ministry said.
Anastasiades, who ran in the election as a candidate from the center-right Democratic Rally (DISY) party, thus secured a second five-year term as president of Cyprus.
The turnout at the vote was 73.97 percent.
Pres Anastasiades is re-elected. #Cyprus continues within the path of stability and growth.— Alexandros Sinka (@a_sinka) 4 февраля 2018 г.
Doing what needs to be done is appreciated by the voters. The citizen remains in the epicenter of our efforts. The challenges ahead of us require the support of the society as a whole. pic.twitter.com/SmYkDjp81Q
The name of the president-elect will be officially announced during a special ceremony at 10 p.m. (20:00 GMT). The swearing-in ceremony is scheduled for February 28.