"According to our medical teams in the port of #Catania #Sicily, at least 56 #people are missing after the first terrible shipwreck of 2018. Among them there were many children who are believed to have drowned at sea," the MSF said on its Twitter page.
The organization added that its psychologists had talked to 14 people, who survived the shipwreck.
The Mediterranean Sea remains a key transition route for migrants and refugees fleeing war and poverty in North African and Middle East countries. In 2017, about 120,000 people arrived in Italy through the Mediterranean route while 2,832 migrants died during the journey, according to the International Organization for Migration (IOM) figures.