DB will pay a £227 million ($340 million) fine to UK's Financial Conduct Authority (FCA), and the rest to the US State Department of Financial Services in New York, the Commodities Futures Trading Commission and the US Department of Justice.
FCA's director for market oversight, Georgina Philippou, said violations were not just sporadic but apparently "deeply ingrained."
"This case stands out for the seriousness and duration of the breaches by Deutsche Bank – something reflected in the size of today's fine," she said.
The UK regulator said 29 employees in London, Frankfurt, Tokyo and New York were involved. The high fine was justified because the German bank also "misled" the regulator, and hampered its investigation.
DB shares dropped 1.8 percent in Frankfurt on the news of the regulators' decision to punish Germany's largest bank, the Financial Times said.
Several other banks have been fined millions of dollars over the past three years as regulators took action to improve industry standards around benchmarks.