The accident occurred at 07:15 p.m. (11:15 GMT) on Friday as the vehicle caught fire at a highway in the city of Changde, the CCTV broadcaster reported. There were reportedly 53 passengers, two drivers and a guide inside the bus at the time of the accident.
All those injured have been hospitalized. Five of them are reportedly in grave condition.
The authorities have detained both drivers and launched a probe into the accident.