The New Zimbabwe news portal reported that the incident took place on a route between the towns of Beitbridge and Gwanda.
According to the correspondent, the explosion could have been caused by gasoline or gas carried by one of the passengers, the outlet added.
Zim Red Cross first aid teams responded to a horrific accident around midnight at the 56km peg from Gwanda towards Beitbridge involving a South African bound bus. A total of 24 people have been ferried to Hospital while the number of deaths is still to be confirmed. pic.twitter.com/GSu3xRHFB7— Zimbabwe Red Cross (@ZrcsRed) 16 ноября 2018 г.
The deadly incident has been confirmed by the police.
The accident came just over a week after a two-bus collision in the northeast of the country that claimed the lives of nearly 50 people.