An official in the Gwer local government, Christopher Avi, stated that at least 50 people died and 70 were wounded after an oil tank truck exploded on Monday.
He said that the truck was trying to avoid potholes, but tumbled, spilling the fuel, which attracted many people to the site of the accident.
The blast has also damaged a nearby bus and several houses.
According to police, the victims, who are mainly from the village of Ahumbe, were taken to local hospitals.
The incident comes after a month ago a similar explosion claimed the lives of 55 people in Niger.