One person was taken to a nearby medical center with life-threatening injuries. Police in riot gear amassed near the entrance to the Omni Hotel, where the incident took place.
NBC reports that the shooting was civilian-on-civilian crime, citing city officials.
North Carolina highway patrol has sent troopers to help the Charlotte police.
According to Fox News, seven cops were taken to area hospitals.
North Carolina Governor Pat McCrory has declared a state of emergency in Charlotte.
A local NBC reporters claims to have seen blood on the ground and police deployed tear gas and flashbangs to disperse the crowd.
Protesters chanted "No justice, no peace," and some were reportedly been arrested.
According to the Charlotte Metropolitan Police, the protests were considered an "unlawful assembly." Authorities began using non-lethal crowd control measures.
— Ely Portillo (@ESPortillo) September 22, 2016
— Justine Miller (@JustineIMiller) September 22, 2016
Rioters attempted to break into nearby stores.
— Mark Boyle (@WCNCmboyle) September 22, 2016
Streetcar service in the city was discontinued.
At least 12 police officers were injured on Tuesday night as demonstrators took to the streets to protest the shooting death of Keith Scott.
— Michael Rathburn (@FantasyRath) September 22, 2016
The family of Keith Lamont Scott, 43, maintains that he had been sitting in his car reading a book when he was approached by a plain-clothed police officer and shot. Charlotte-Mecklenburg Police Chief Kerr Putney stated that while the officer was in plain clothes, he was accompanied by officers who were in uniform, and that a handgun, and no book, was found at the scene.