"They [results] were predictable and are further proof that the conflict should be resolved in line with available agreements," Sergei Lavrov said.
Lavrov said the departure of one of the parties to the talks, which Moldova did, could lead to a new crisis.
In televised remarks last week, Lavrov said the economic situation in the region was being aggravated by the new customs regulations imposed by Ukraine in March. The new regulations require that exports from Transdnestr pass preliminary clearance in Moldova, and Transdnestr claims the move was orchestrated by Moldova.
Transdnestr said at the time that sanctions were tantamount to an economic blockade, and President Igor Smirnov withdrew from the talks, saying Transdnestr was subjected to pressure.
Lavrov said earlier the referendum was Transdnestr's attempt to draw attention to the unresolved problems facing the region and resume the talks.
More than 389,000 registered voters were asked to answer two questions: whether they want the Transdnestr Region to maintain its independence from Moldova and eventually join Russia, or whether they believe the region should become part of Moldova.
The election committee said 78.6% of voters participated in the referendum. According to preliminary results, 97.1% of voters cast their ballots in favor of independence and a union with Russia.
Russia, which has maintained troops in the region with a predominantly Russian-speaking population since a bloody conflict with Moldova in the 1990s, has not expressed official willingness to annex Transdnestr, which has no common border with Russia.
But unlike Western countries, which have consistently refused to recognize Transdnestr's independence, Russian officials said the referendum outcome should be recognized.
"Hundreds of observers from the CIS [union of ex-Soviet republics] and Europe could see with their own eyes what people in Transdnestr are striving for," Lavrov said.
On Monday, the Transdnestrian leader urged a package of laws be adopted to bring local legislation in the sphere of finance, economics, taxation, customs, welfare and education closer to Russia's.
"I have also ordered the Republican Bank to look into the possibility of joining the Russian ruble zone," Smirnov said
